Nuclear Factor Kappa Beta Signaling Module

Citation
Hoffmann A,Levchenko A,Scott ML,Baltimore D (2002) The I-kappa-Beta-NF-kappa-Beta signaling module: temporal control and selective gen activation.Science, 298:1241. http://www.sciencemag.org/cgi/content/abstract/298/5596/ 1241
Description
Nuclear localization of the transcriptional activator NFkB ( nuclear factor kappa beta) is controlled in mammalian cells by three isoforms of NFkB inhibitor protein: IkBa (I-Kappa-Beta-alpha),IkBd (I-Kappa-Beta-Delta), and IkBe (I-Kappa-Beta-Epsilon) .Based on simplifying reductions of the IkB/ NFkB signaling module in knockout cell lines, the authors present a computational model that describes the temporal control of NFkB activation by the coordinated degradation and synthesis of IkB proteins.
Rate constant       Reaction
a1 = 30 IkBa + NFkB -> IkBa_NFkB
a1 = 30 IkBan + NFkBn -> IkBan_NFkBn
a2 = 30 IKK_IkBa + NFkB -> IKK_IkBa_NFkB
a3 = 1.35 IkBa + IKK -> IKK_IkBa
a4 = 11.1 IkBa_NFkB + IKK -> IKK_IkBa_NFkB
adapt = 0.0072 IKK -> EmptySet
d1 = 0.03 IkBan_NFkBn -> IkBan + NFkBn
d1 = 0.03 IkBa_NFkB -> IkBa + NFkB
d2 = 0.03 IKK_IkBa_NFkB -> IKK_IkBa + NFkB
d3 = 0.0075 IKK_IkBa -> IkBa + IKK
d4 = 0.105 IKK_IkBa_NFkB -> IkBa_NFkB + IKK
deg1 = 0.00135 IkBa_NFkB -> NFkB
deg2 = 0.00675 IkBa -> EmptySet
deg3 = 0.0168 IkBat -> EmptySet
k1 = 1.221 IKK_IkBa_NFkB -> IKK + NFkB
k2 = 0.2442 IKK_IkBa -> IKK
tr1 = 5.4 NFkB -> NFkBn
tr2 = 0.0048 NFkBn -> NFkB
tr3 = 0.018 IkBa -> IkBan
tr4 = 0.012 IkBan -> IkBa
tr5 = 0 IkBa_NFkB -> IkBan_NFkBn
tr6 = 0.82944 IkBan_NFkBn -> IkBa_NFkB
trb = 0.0000921375 EmptySet -> IkBat
Generated by Cellerator Version 1.0 update 3.0303 using Mathematica 4.2 for Mac OS X (August 22, 2002), March 17, 2003 17:31:27